MCSim-related pages
-
GNU MCSim page on Wikipedia
-
Journal of Statistical Software
- Data on Statlib for
Gelman, Bois, Jiang, JASA, 1996 paper
- SAL-Numerical Analysis
- Duke University:
Institute of Statistics and Decision Sciences
- University of Bristol: Neural Network
Information
-
Pasteur Institute: Software
- Molecular Monte Carlo Software
- Delorie Free
Software
- A
real conversation supported by an MCSim simulation model
Scientific works acknowledging the use of MCSim
- Allen, B.C., Hack E.C., Clewell H.J., 2007,
"Use of Markov chain Monte Carlo analysis with a physiologically-based
pharmacokinetic model of methylmercury to estimate exposures in
u.s. women of childbearing age".
Risk Analysis, 27:947-959.
- Banks H.T., Ma Y., Potter, L.K., 2005,
"A Simulation-based comparison between parametric and nonparametric
estimation methods in PBPK Models",
Journal of Inverse and Ill-posed Problems, 13:126.
- Bernillon P., Bois F., 2000,
"Statistical issues in toxicokinetic modeling: A Bayesian perspective",
Environmental Health Perspectives, 108(suppl.5):883-893.
- Bois F., 1999,
"Analysis of PBPK models for risk characterization."
Annals of the New York Academy of Sciences 895: 317-337.
- Bois F., 2000,
"Statistical analysis of Clewell et al. PBPK model of trichloroethylene
kinetics."
Environmental Health Perspectives 108 (suppl. 2): 307-316.
- Bois F., 2000,
"Statistical analysis of Fisher et al. PBPK model of trichloroethylene
kinetics."
Environmental Health Perspectives 108 (suppl. 2): 275-282.
- Bois F., 2001,
"Applications of population approaches in toxicology."
Toxicology Letters 120:385-394.
- Bois F., 2003,
"Toxicokinetic modelling of 2,3,7,8-tetrachloro-p-dioxin blood
concentration after ingestion by women."
Environnement, Risque et Sante 2:45-53.
- Bois F., Fahmy T., et al., 1997,
"Dynamic modeling of bacteria in a pilot drinking water distribution
system."
Water Research 31:3146-3156.
- Bois F., Gelman A., et al., 1996,
"Population toxicokinetics of tetrachloroethylene."
Archives of Toxicology 70: 347-355.
- Bois F., Jackson E., et al., 1996,
"Population toxicokinetics of benzene."
Environmental Health Perspectives 104 (suppl. 6): 1405-1411.
- Bois F., Krowech G., et al., 1995,
"Human interindividual variability in metabolism: the example
of 4-aminobiphenyl."
Risk Analysis 15: 205-213.
- Bois F., Maszle D., 1997,
MCSim: A simulation program,
Journal of Statistical Software,
2(9):http://www.stat.ucla.edu/journals/jss/v02/i09.
- Bois F., Paxman D., 1992,
"An analysis of exposure rate effects for benzene using a physiologically
based pharmacokinetic model."
Regulatory Toxicology and Pharmacology 15: 122-136.
- Bois F., Smith M., et al., 1991,
"Mechanisms of benzene carcinogenesis: application of a physiological
model of benzene pharmacokinetics and metabolism."
Toxicology Letters 56: 283-298.
- Bois F., Smith T., et al., 1999,
"Optimal design for a study of butadiene toxicokinetics in humans."
Toxicological Sciences 49: 213-224.
- Bois F., Woodruff T.J., et al., 1991,
"Comparison of three physiologically-based pharmacokinetic models of
benzene disposition."
Toxicology and Applied Pharmacology 110: 79-88.
- Bois F., Zeise L., et al., 1990,
"Precision and sensitivity analysis of pharmacokinetic models for cancer
risk assessment: tetrachloroethylene in mice, rats and humans."
Toxicology and Applied Pharmacology 102: 300-315.
- Brochot C., Bessoud B., et al., 2006,
"Evaluation of antiangiogenic treatment effects on tumors microcirculation
by Bayesian physiological pharmacokinetic modeling and magnetic resonance
imaging."
Magnetic Resonance Imaging, 24:1059-1067.
- Brochot C., Bois F., 2005,
"Use of a chemical probe to increase safety for human volunteers in
toxicokinetic studies".
Risk Analysis 25:1559-1571.
- Brochot C., Marchand S., Couet W., Gelman A., Bois F., 2004,
"Extension of the isobolographic approach to interactions studies between
more than two drugs: Illustration with the convulsant interaction between
pefloxacin, norfloxacin and theophylline in rats".
Journal of Pharmaceutical Sciences, 93:553-562.
- Brochot C., Smith T.J., Bois F., 2007,
"Development of a physiologically based toxicokinetic model for butadiene
and four major metabolites in humans: Global sensitivity analysis for
experimental design issues".
Chemico-Biological Interactions, 167:168-183.
- Cancre N., Bois F., et al., 1999,
"Screening blood donations for hepatitis C in central Africa: Analysis
of a risk- and cost-based decision tree".
Medical Decision Making, 19:296-306.
- Cancre N., Tall A., et al., 2000,
"Bayesian analysis of an epidemiological model of P. falciparum malaria
infection in Ndiop, Senegal".
American Journal of Epidemiology, 152:760-770.
- Chiu W.A., Bois F., 2006,
"Revisiting the population toxicokinetics of tetrachloroethylene".
Archives of Toxicology, 80:386-386.
- Chiu W.A., Bois F., 2007,
"An approximate method for population toxicokinetic analysis with aggregated
data".
Journal of Agricultural, Biological, and Environmental Statistics,
12:346-363.
- Chiu W.A., Micallef S., Monster A.C., Bois F., 2007,
"Toxicokinetics of inhaled trichloroethylene and tetrachloroethylene in
humans at 1 ppm: Empirical results and comparisons with previous studies".
Toxicological Sciences, 95:23-36.
- Covington T.R., Gentry P.R., et al., 2007,
"The use of Markov chain Monte Carlo uncertainty analysis to support a
Public Health Goal for perchloroethylene",
Regulatory Toxicology and Pharmacology, 47:1-18.
- David, R. M., H. J. Clewell, et al., 2006,
"Revised assessment of cancer risk to dichloromethane II. Application of probabilistic methods to cancer risk determinations."
Regulatory Toxicology and Pharmacology 45: 55-65.
- Diack C., Bois F., 2005,
"Pharmacokinetic-pharmacodynamic models for
categorical toxicity data,"
Regulatory Toxicology and Pharmacology, 41:55-65.
- Eisenberg J.N, Seto E., et al, 1996,
"Quantifying water pathogen risk in an epidemiological framework",
Risk Analysis, 16:549-563.
- Franks S.J., Spendiff M.K., et al., 2006,
"Physiologically based pharmacokinetic modelling of human
exposure to 2-butoxyethanol",
Toxicology Letters 162 (2006) 164173.
- Gelman A., Bois F., Jiang J., 1996,
"Physiological pharmacokinetic analysis using population modeling and
informative prior distributions,"
Journal of the American Statistical Association, 91:1400-1412.
- Hack E.C., 2006,
"Bayesian analysis of physiologically based toxicokinetic and
toxicodynamic models".
Toxicology, 221:241-248.
- Hack E.C., Chiu W.A, et al., 2006,
"Bayesian population analysis of a harmonized physiologically based
pharmacokinetic model of trichloroethylene and its metabolites",
Regulatory Toxicology and Pharmacology, 46:63-83.
- Johanson G., Jonsson F., Bois F., 1999,
"Development of new technique for risk assessment using physiologically
based toxicokinetic models",
American Journal of Industrial Medecine, Suppl. 1:101-103.
- Jonsson F, Jonsson E.N., Bois F., Marshall S., 2007, The application of a Bayesian approach to the analysis of a complex, mechanistically based model, Journal of Biopharmaceutical Statistics, 17:65-92.
- Jonsson F., Bois F., Johanson G., 2001, Assessing the reliability of PBPK models using data from methyl chloride-exposed, non-conjugating human subjects, Archives of Toxicology, 75:189-199.
- Jonsson F., Bois F., Johanson G., 2001, Physiologically based pharmacokinetic modeling of inhalation exposure of humans to dichloromethane during moderate to heavy exercise, Toxicological Sciences, 59:209-218.
- Jonsson, F. and G. Johanson, 2003,
"The Bayesian population approach to physiological toxicokinetic-toxicodynamic models - An example using the MCSim software."
Toxicology Letters 138: 143-150.
- Liao K.H., Tan Y.-M., et al.,2007,
"Bayesian estimation of pharmacokinetic and pharmacodynamic parameters
in a mode-of-action-based cancer risk assessment for chloroform",
Risk Analysis, 27:1535-1551.
- Lin H.I., Berzins D.W., et al., 2004,
"A Bayesian approach to parameter estimation for a crayfish (procambarus spp.)
bioaccumulation model".
Environmental Toxicology and Chemistry: Vol. 23, No. 9 pp. 22592266.
- Loizou G., Spendiff M., 2005,
"A human PBPK model for ethanol describing inhibition of gastric motility",
Journal of Molecular Histology, 35:687-696.
- Lyons M.A., Yang R.S.H, 2008,
"Computational toxicology of chloroform: reverse dosimetry using Bayesian
inference, Markov chain Monte Carlo simulation, and human biomonitoring
data",
Environmental Health Perspectives, 116:10401046.
- Marino, D. J., H. Clewell, et al., 2006,
"Revised assessment of cancer risk to dichloromethane: part I Bayesian PBPK
and dose-response modeling in mice".
Regulatory Toxicology and Pharmacology 45: 44-54.
- Mezzetti M., Ibrahim J.G., et al., 2003,
"A Bayesian compartmental model for the evaluation of 1,3-butadiene
metabolism".
Journal of the Royal Statistical Society, Series C, 52:291-305.
- Micallef S., Amzal B., Bach V., Chardon K., Tourneux P., Bois F., 2007, Sequential updating of a new dynamic pharmacokinetic model for caffeine in premature neonates, Clinical Pharmacokinetics, 46:59-74.
- Micallef, S., Bois F., 2004, [Application of physiological models to toxicokinetic data analysis], Journal de la Societe Franaise de Statistique, 145:15-32.
- Micallef, S., Brochot, C., Bois F., 2005, [Bayesian statistical analysis of toxicokinetic data], Environnement, Risque et Sante, 4:21-34.
- Nong, A., Y. M. Tan, et al., 2008,
"Bayesian calibration of a
physiologically based pharmacokinetic/pharmacodynamic model of
carbaryl cholinesterase inhibition."
Journal of Toxicology and Environmental Health - Part A - Current Issues 71(20):
1363-1381.
- Smith T., Bois F., Lin Y.-S., Brochot C., Micallef S., Kim D., Kelsey K.T., 2008, Quantifying heterogeneity in exposure-risk relationships using exhaled breath biomarkers for 1,3-butadiene exposures, Journal of Breath Research, 2:037018 (10 p.)
- Smith T., Lin Y.-S., Mezzetti L., Bois F., Kelsey K., Ibrahim J., 2001, Genetic and dietary factors affecting human metabolism of 1,3-butadiene, Chemico-Biological Interactions, 135-136, special issue):407-428.
- Spear R., Bois F., 1994, Parameter variability and the interpretation of physiologically based pharmacokinetic modeling results, Environmental Health Perspectives, 102(suppl. 11):61-66.
- Spear R., Bois F., et al., 1991,
"Modeling benzene pharmacokinetics: Calibration and parametric sensitivity
across three sets of animal data",
Risk Analysis, 11:641-654.
- Verotta D., 2005,
"Models and estimation methods for clinical HIV-1 data",
Journal of Computational and Applied Mathematics, 184:275-300.
- Watanabe K., Bois F., 1996, Interspecies extrapolation of physiological pharmacokinetic parameter distributions, Risk Analysis, 16:741-754.
- Watanabe K.H., Bois F., et al., 1994,
"Benzene toxicokinetics in humans: Bone marrow exposure to metabolites",
Occupational and Environmental Medicine, 51:414-420.
- Watanabe K.H., Lin H.-I., 2005,
"Bayesian estimation of kinetic rate constants in a food-web model
of polycyclic aromatic hydrocarbon bioaccumulation",
Ecological Modelling 181:229246.
- Woodruff T., Bois F., et al., 1992,
"Structure and parametrization of toxicokinetic models: Their impact on
model predictions",
Risk Analysis, 12:189-201.
- Woodruff T.J., Bois F., 1993,
"Optimization issues in physiological toxicokinetic modeling: A case study
with benzene",
Toxicology Letters, 69:181-196.
- Yokley K. Tran H.T., et al., 2006
"Physiologically-based pharmacokinetic modeling of benzene in humans:
A Bayesian approach",
Risk analysis, 26:925-943.